What is Methylate? And its function in Vitamin – Vitamins and Supplements Online Canada - Shop With Free Shipping

Free Shipping - Buy 2+ Products, Get 20% Off With Code "VORST20"

What is Methylate? And its function in Vitamin

What is Methylate? And its function in Vitamin

Disclaimer: This content has been produced purely for informational and educational purposes only and is never intended to be used as a substitute for professional medical guidelines, including diagnosis, advice, and treatment.

Table of Content

  • Introduction
  • Understanding Methylation
  • Methylation in Vitamins
  • Function of Methylation in Vitamins
  • Importance of Methylated Vitamins
  • Conclusion

Methylation, a fundamental biochemical process in the human body, plays a pivotal role in various physiological functions. It involves the addition of a methyl group (CH3) to molecules, such as DNA, proteins, and neurotransmitters, thereby modulating their activity and function. One crucial aspect of methylation lies in its interaction with vitamins, essential micronutrients vital for overall health and well-being. Understanding the intricate relationship between methylation and vitamins sheds light on the significance of methylated vitamins in maintaining optimal health.

Understanding Methylation

Methylation is a biochemical process that involves the transfer of a methyl group from one molecule to another. This transfer is catalyzed by enzymes known as methyltransferases, utilizing S-adenosyl methionine (SAM) as the methyl donor. Methylation occurs on various biomolecules, including DNA, RNA, proteins, lipids, and neurotransmitters. Its primary function is to regulate gene expression, control protein function, and modulate the activity of numerous cellular processes.

Methylation in Vitamins

Several vitamins participate in or are affected by methylation processes within the body. These include B vitamins such as folate (B9), vitamin B12 (cobalamin), vitamin B6 (pyridoxine), riboflavin (B2), and choline. These vitamins serve as cofactors or substrates for enzymes involved in methylation reactions, facilitating the transfer of methyl groups to various biomolecules.

Function of Methylation in Vitamins

The methylation of vitamins serves several critical functions in the body. For instance, folate and vitamin B12 are essential for DNA methylation, a process crucial for regulating gene expression and maintaining genomic stability. Vitamin B6 plays a role in neurotransmitter synthesis through the methylation of neurotransmitter precursors. Choline, another methyl donor, is necessary for the synthesis of phospholipids, which are vital components of cell membranes.

Importance of Methylated Vitamins

Methylated forms of vitamins are particularly important for individuals with certain genetic variations or underlying health conditions that impair their ability to metabolize or utilize traditional forms of vitamins. Methylated vitamin forms are already in a bioavailable state, bypassing the need for conversion in the body, which can be problematic for those with impaired enzyme function. For example, methylated forms of folate and vitamin B12 are often recommended for individuals with MTHFR gene mutations, as these individuals may have difficulty converting non-methylated forms of these vitamins into their active forms.

Furthermore, methylated vitamins are generally more stable and have better absorption rates compared to non-methylated forms, ensuring that the body can readily utilize them for essential biochemical processes. Their increased bioavailability makes them particularly beneficial for individuals with malabsorption issues or gastrointestinal disorders that affect nutrient absorption.


In conclusion, methylation is a vital biochemical process that influences numerous physiological functions in the body. Its interaction with vitamins, particularly methylated forms, underscores the importance of these micronutrients in maintaining optimal health. Methylated vitamins serve as essential cofactors for enzymes involved in methylation reactions, ensuring the proper functioning of various cellular processes. Understanding the significance of methylated vitamins not only highlights their role in health maintenance but also emphasizes their relevance in personalized nutrition strategies, especially for individuals with specific genetic or health-related considerations.

References and Resources