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Indole 3 Carbinol for Endometriosis

indole 3 carbinol for endometriosis


DISCLAIMER: This article has been written for informational and educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment.


In today’s stressful lifestyle, endometriosis has become a common condition, affecting around 200 million women globally. According to the Endometriosis Foundation of America (EndoFound), the disease is mostly either misdiagnosed or missed altogether. 

While conventional treatments of endometriosis appear hard and often cause unpleasant adverse effects, natural treatment options including indole 3 carbinol for endometriosis are described to be effective in addressing the root causes more safely.

Here we’ll unfold how indole 3 carbinol can help with endometriosis naturally according to scientific studies. But, before we get started with the benefits of the indole 3 carbinol supplement on endometriosis, it’s important to learn the basics of disease a little bit more.    

Table of contents 

  • What is endometriosis? 
  • Symptoms of endometriosis
  • Causes of endometriosis 
  • Risk factors for endometriosis 
  • Complications of endometriosis
  • What is indole 3 carbinol?
  • How indole 3 carbinol can help with endometriosis 
  • How to use indole 3 carbinol 
  • Precautions and side effects 
  • Final words 

What is endometriosis? 

Endometriosis is a painful female disorder in which tissues similar to endometrial tissues are found outside the uterus. Endometrial tissues normally line the endometrium, but in endometriosis, they might grow in fallopian tubes, ovaries, and other areas of the pelvis. These mislocated endometrial tissues affect hormones that are involved in periodic cycles and wreak havoc in several ways. 

Symptoms of endometriosis 

The major symptom of endometriosis is cramping and pain in the pelvic region that’s often appeared with menstrual periods. 

The most common symptoms of endometriosis may include - 

  • Dysmenorrhea or painful periods 
  • Pain during or after an intercourse 
  • Pain with urination or bowel movements 
  • Heavy menstrual bleeding or intermenstrual bleeding between periods 
  • Infertility 
  • Fatigue 
  • Gastrointestinal issues such as constipation, diarrhea, bloating, or nausea  

Causes of endometriosis 

While the actual reason for endometriosis is yet unclear, there’re several explanations on how an endometriosis condition may develop. Some possible factors are stated below. 

  • Retrograde menstruation is a condition where menstrual blood that contains endometrial tissue flows backward towards the pelvic cavity through the fallopian tubes to implant and grow in many places in the pelvis. 

  • Peritoneal cell transformation where peritoneal cells that normally line the inner part of the abdomen are transformed into endometrial-like tissues by hormonal or immune system malfunction. 

  • Transformation of embryonic cells where embryonic cells are transformed into endometrial-like tissue implants during the early stages of fetal development by hormones such as estrogen. 

Other causes may include - 

  • Surgical incision
  • Hormonal imbalance 
  • Immune system dysfunction
  • Excess exposures to environmental toxins and pollutants
  • Inflammation 
  • Genetic factor 

Risk factors for endometriosis 

There’re several factors that may increase the risk of developing endometriosis. They may include: 

  • Starting of the period earlier than usual 
  • Never giving birth 
  • Menopause 
  • Shorter menstrual cycle with less than 27 days 
  • Excessive menstrual bleeding that may last more than 7 days 
  • Experiencing estrogen dominance in the body 
  • Low BMI (body mass index)
  • Lifetime exposure to environmental estrogens 
  • Having a family history (mother or sister) of endometriosis 
  • Issues of the reproductive tract 
  • Any disease that blocks blood passages during menstrual periods 

Complications of endometriosis 

There’re two main complications - infertility and ovarian cancer. According to data, around half of women who have endometriosis experience difficulty in getting pregnant. Besides, it increases the risk of developing ovarian cancer and sometimes endometriosis-associated adenocarcinoma.  

What is indole 3 carbinol? 

Indole 3 carbinol, also known as I3C, is a resulting substance formed by the breaking down of the indole glucosinolate commonly called glucobrassicin, which is present at excess levels in many cruciferous vegetables including cauliflower, cabbage, broccoli, kale, brussels sprouts, and collard greens. It can influence a variety of cellular processes and help promote human health by balancing bodily functions. 

How indole 3 carbinol can help with endometriosis

Indole 3 carbinol or I3C is a highly beneficial supplement that can help endometriosis in many ways. Several studies have been made to review its effects on endometriosis and it has been found potential in reducing estrogen dominance which is the primary contributor to the development of endometriosis. 

Studies have found that indole 3 carbinol can help maintain a healthy balance between 2 hydroxy and 16 hydroxy estrogen molecules and can help alleviate bleeding, pain, inflammation, and other associated symptoms of endometriosis.

Research suggests that DIM or di-indolyl-methane is the key compound that’s responsible for indole 3 carbinol’s beneficial effects on endometriosis. The majority of supplementary indole 3 carbinol is assimilated in the gastrointestinal (GI) tract as DIM and helps improve endometriosis conditions in women. 

Indole 3 carbinol also plays an essential role in supporting optimal reproductive wellness in females as well. 


How to use indole 3 carbinol 

Though the actual dose may differ depending on the severity of the condition. In most cases, healthcare professionals recommend indole 3 carbinol for endometriosis with doses of 200 mg to 400 mg per day. 

However, it’s recommended to discuss with a certified naturopathic doctor before using indole 3 carbinol so that he or she can determine whether it’s right for your specific condition. 

Precautions and side effects

Indole 3 carbinol is possibly safe for most people when taken with recommended doses. Overdoses may cause some side effects such as skin rashes, nausea, tremor, and balance issues, but these aren’t common. 

I3C may also interact with certain medications especially those that are broken down by the liver. Besides, there’s not enough information regarding the safety of using indole 3 carbinol during pregnancy and breastfeeding. 

Hence, consult with a licensed naturopathic doctor prior to using indole 3 carbinol especially if you’re pregnant, or breastfeeding, or taking any medication.  

Final words 

Indole 3 carbinol has been found highly beneficial in reducing bleeding, pain, and inflammation in endometriosis. Several modern studies have proved the beneficial effects of indole 3 carbinol for endometriosis. It also supports the female reproductive system as well. 

But, ask for direct supervision from a medical doctor prior to using indole 3 carbinol for endometriosis.  

Kindly check out Vorst’s pure and natural Indole 3 Carbinol I3C 400 mg Vegan Capsules here. 

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